Article

Structural basis of <i>γ</i> -chain family receptor sharing at the membrane level

2023-05-06

Abstract excerpt

The common γ-chain (γc) family of cytokine receptors, including interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors, are activated upon engagement with the common γc receptor in ligand dependent manner. Sharing of γc by the IL receptors (ILRs) is thought to be achieved by concomitant binding of γc and ILR ectodomains to a cytokine. Here, we found that direct interactions between the transmembrane doma...

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Literature Corpus work: cfe5d3a0-7315-55c6-9c0b-4f71aa8efaf0
DOI: 10.1101/2023.05.05.539662

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