Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Astroglial c-Myc Overexpression Predisposes Mice to Primary Malignant Gliomas

28 Feb 2003

Abstract excerpt

Malignant astrocytomas are common human primary brain tumors that result from neoplastic transformation of astroglia or their progenitors. Here we show that deregulation of the c-Myc pathway in developing astroglia predisposes mice to malignant astrocytomas within 2-3 weeks of age. The genetically engineered murine (GEM) gliomas harbor a molecular signature resembling that of human primary glioblastoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Neurogenesis and neuroplasticity mechanisms
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12501251
DOI: 10.1074/jbc.m211195200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astroglial c-Myc Overexpression Predisposes Mice to Primary Malignant GliomasPMID 12501251Read ↗

Insights gained from modelling high‐grade glioma in the mouseSemantic proximity Read ↗

Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.Semantic proximity Read ↗

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural PhenotypeSemantic proximity Read ↗

Mouse Models to Interrogate the Implications of the Differentiation Status in the Ontogeny of GliomasSemantic proximity Read ↗

A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomasSemantic proximity Read ↗

In vivo mouse models for adult brain tumors: Exploring tumorigenesis and advancing immunotherapy developmentSemantic proximity Read ↗

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.Semantic proximity Read ↗

Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBMSemantic proximity Read ↗

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cellsSemantic proximity Read ↗

A syngeneic glioblastoma mouse model with mesenchymal hallmarks.Semantic proximity Read ↗

In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studiesSemantic proximity Read ↗

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.