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Article

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

23 May 2011

Abstract excerpt

BACKGROUND: Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into distinct subtypes: Proneural, Neural, Classical and Mesenchymal. The signatures of these different tumor subtypes may reflect the phenotypes of cells giving rise to them. However, the experimental evidence connecting any specific subtype of GBM...

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PMID: 21625383
DOI: 10.1371/journal.pone.0020041

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