Article
Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.
Journal of visualized experiments : JoVE - 12 Aug 2014
McNeill Robert S, Schmid Ralf S, Bash Ryan E, Vitucci Mark, White Kristen K, Werneke Andrea M, Constance Brian H, Huff Byron, Miller C Ryan
Abstract excerpt
Current astrocytoma models are limited in their ability to define the roles of oncogenic mutations in specific brain cell types during disease pathogenesis and their utility for preclinical drug development. In order to design a better model system for these applications, phenotypically wild-type cortical astrocytes and neural stem cells (NSC) from conditional, genetically engineered mice (GEM) that harbor...
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