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Article

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.

Brain pathology (Zurich, Switzerland) - 1 Jan 2017

Irvin David M, McNeill Robert S, Bash Ryan E, Miller C Ryan

Abstract excerpt

The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were susceptible to these mutations. We therefore used genetic lineage tracing and fate mapping in adult conditional,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26762242
DOI: 10.1111/bpa.12348
PMCID: PMC5322824

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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