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Article

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

15 May 2017

Abstract excerpt

Group3 medulloblastoma (MB G3 ) that predominantly occur in young children are usually associated with MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis. Physiologically relevant MB G3 models are currently lacking, making inferences related to their cellular origin thus far limited. Using in utero electroporation, we here report that MB G3 mouse models can be developed in situ...

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PMID: 28504719
DOI: 10.1038/onc.2017.110

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