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In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies

9 Jul 2014

Abstract excerpt

Although our knowledge of the biology of brain tumors has increased tremendously over the past decade, progress in treatment of these deadly diseases remains modest. Developing in vivo models that faithfully mirror human diseases is essential for the validation of new therapeutic approaches. Genetically engineered mouse models (GEMMs) provide elaborate temporally and genetically controlled systems to investigate...

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PMID: 25008045
DOI: 10.1007/s00018-014-1675-3

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