Article
A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2003
Wu Jianming, Metz Christine, Xu Xiulong, Abe Riichiro, Gibson Andrew W, Edberg Jeffrey C, Cooke Jennifer, Xie Fenglong, Cooper Glinda S, Kimberly Robert P
Abstract excerpt
A single-nucleotide polymorphism (SNP), identified at nucleotide position -844 in the 5' promoter of the FasL gene, lies within a putative binding motif for CAAT/enhancer-binding protein beta (C/EBPbeta). Electrophoretic mobility shift and supershift assays confirmed that this element binds specifically to C/EBPbeta and demonstrated that the two alleles of this element have different affinities for C/EBPbeta. In...
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