Article
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
PloS one - 1 Jan 2011
Wu Jianming, Richards Maureen H, Huang Jinhai, Al-Harthi Lena, Xu Xiulong, Lin Rui, Xie Fenglong, Gibson Andrew W, Edberg Jeffrey C, Kimberly Robert P
Abstract excerpt
FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells. In addition to the functional FasL SNP -844C>T (rs763110), three other SNPs (SNP -756A>G or rs2021837, SNP -478A>T or rs41309790, and SNP -205 C>G or rs74124371)...
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