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Article

Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.

Genes and immunity - 1 Dec 2005

Nolsøe R L, Kelly J A, Pociot F, Moser K L, Kristiansen O P, Mandrup-Poulsen T, Harley J B

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens and tissue injury. Defective apoptosis of activated immune cells leads to the development of autoantibodies in SLE. FasL initiated apoptosis is central for peripheral tolerance. Fas deficiencies in humans and mice predispose toward systemic autoimmunity. SLE is conferred by...

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Source

Identifiers

PMID: 16163374
DOI: 10.1038/sj.gene.6364259

Genes

FAS
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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