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Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP.

Biochimica et biophysica acta - 1 Nov 2016

Awah Chidiebere U, Tamm Stephanie, Hedtfeld Silke, Steinemann Doris, Tümmler Burkhard, Tsiavaliaris Georgios, Stanke Frauke

Abstract excerpt

A challenging question in genetics is to understand the molecular function of non-coding variants of the genome. By using differential EMSA, ChIP and functional genome analysis, we have found that changes in transcription factors (TF) apparent binding affinity and dissociation rates are responsible for allele specific assembly or disruption of master TFs: we observed that NF-KBp50, NF-KBp65 and HIF1a bind with an...

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Identifiers

PMID: 27616356
DOI: 10.1016/j.bbagrm.2016.09.002

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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