FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population.

doi:10.1016/j.humimm.2012.06.001

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Article

FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population.

Human immunology - 1 Sept 2012

Mahfoudh Wijden, Bouaouina Noureddine, Gabbouj Sallouha, Chouchane Lotfi

Abstract excerpt

The single nucleotide polymorphism, rs763110 (-844 T/C) of the FASL gene, is located within a putative binding motif of CAAT/enhancer-binding protein β transcription factor. Higher basal expression of FASL is significantly associated with the FASL-844 C allele compared with the FASL-844 T allele suggesting that the FASL-844 T/C polymorphism may influence FASL expression and FASL-mediated signalling, and...

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PMID: 22732091
DOI: 10.1016/j.humimm.2012.06.001

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