Article
A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus.
The Journal of rheumatology - 1 Jun 2002
Kanemitsu Satomi, Ihara Kenji, Saifddin Ahmed, Otsuka Takeshi, Takeuchi Tsutomu, Nagayama Jun, Kuwano Michihiko, Hara Toshiro
Abstract excerpt
OBJECTIVE: To investigate whether Fas promoter polymorphisms show a genetic contribution to the development of systemic lupus erythematosus (SLE) in a Japanese population, and to study the functional difference in promoter activity of the polymorphisms. METHODS: In 109 SLE patients and 140 controls, the frequencies of A/G polymorphisms at -670 nucleotide position and G/A at -1377 nucleotide position were...
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