Article
The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE.
Genes and immunity - 1 Mar 2005
Chen J-Y, Wang C-M, Ma C-C, Chow Y-H, Luo S-F
Abstract excerpt
FasL expression is critical in T-cell activation-induced apoptosis, which is involved in lupus pathogenesis. This study identified two SNPs in the FasL promoter regions from -1145 to -45 by genomic DNA sequencing. The -844C/T polymorphism was previously described by its location in and affect on the CCAAT/enhancer-binding protein beta (C/EBPB beta)-binding site and the other (-1094A/C, a novel polymorphism) was...
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