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Article

Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice.

Infection and immunity - 1 Jan 2003

Sánchez Fabio, Radaeva Tatiana V, Nikonenko Boris V, Persson Ann-Sophie, Sengul Selim, Schalling Martin, Schurr Erwin, Apt Alexander S, Lavebratt Catharina

Abstract excerpt

Following challenge with virulent Mycobacterium tuberculosis, mice of the I/St inbred strain exhibit shorter survival time, more rapid body weight loss, higher mycobacterial loads in organs, and more severe lung histopathology than mice of the A/Sn strain. We previously performed a genome-wide scan for quantitative trait loci (QTLs) that control the severity of M. tuberculosis-triggered disease in [(A/Sn x I/St)...

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Identifiers

PMID: 12496157
DOI: 10.1128/IAI.71.1.126-131.2003
PMCID: PMC143141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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