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Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice.

Genes and immunity - 1 Dec 2000

Mitsos L M, Cardon L R, Fortin A, Ryan L, LaCourse R, North R J, Gros P

Abstract excerpt

Genetic factors play a key role in host response, disease severity, and ultimate outcome of infection with Mycobacterium tuberculosis in humans. In the mouse, the DBA/2J strain is very susceptible to M. tuberculosis H37Rv infection, while the C57Bl/6J strain is resistant. In DBA/2J, a heavier bacterial burden causes a unique phenotype, that includes very severe and rapidly fatal pulmonary disease with extensive...

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Identifiers

PMID: 11197687
DOI: 10.1038/sj.gene.6363712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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