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Article

Immunological roads diverged: mapping tuberculosis outcomes in mice.

Trends in microbiology - 1 Jan 2025

Meade Rachel K, Smith Clare M

Abstract excerpt

The journey from phenotypic observation to causal genetic mechanism is a long and challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes tuberculosis (TB), host-pathogen coevolution has spanned millennia, costing millions of human lives. Mammalian models can systematically recapitulate host genetic variation, producing a spectrum of disease outcomes. Leveraging genome sequences and...

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Source

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Identifiers

PMID: 39034171
DOI: 10.1016/j.tim.2024.06.007
PMCID: PMC13527666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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