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Article

Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs.

Proceedings of the National Academy of Sciences of the United States of America - 27 May 2003

Mitsos Loukia-Maria, Cardon Lon R, Ryan Lynn, LaCourse Ronald, North Robert J, Gros Philippe

Abstract excerpt

The mouse DBA/2 (D2) strain is very susceptible to infection with virulent Mycobacterium tuberculosis, whereas C57BL/6 (B6) is much more resistant. Infection of D2 and B6 mice with M. tuberculosis H37Rv by the respiratory route is biphasic: during the first 3 weeks, there is rapid bacterial growth in the lung of both strains, whereas beyond this point replication stops in B6 but continues in D2, causing rapidly...

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Identifiers

PMID: 12740444
DOI: 10.1073/pnas.1031727100
PMCID: PMC164495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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