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Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent mice

5 Jul 2023

Abstract excerpt

Genetic differences among mammalian hosts and among strains of Mycobacterium tuberculosis (Mtb) are well-established determinants of tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon mutagenesis and sequencing approaches has enabled dissection of complex host-pathogen interactions. To identify host and pathogen genetic determinants of Mtb...

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PMID: 37405387
DOI: 10.1093/g3journal/jkad147

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