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Article

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.

PLoS pathogens - 1 Jul 2016

Chella Krishnan Karthickeyan, Mukundan Santhosh, Alagarsamy Jeyashree, Hur Junguk, Nookala Suba, Siemens Nikolai, Svensson Mattias, Hyldegaard Ole, Norrby-Teglund Anna, Kotb Malak

Abstract excerpt

Host genetic variations play an important role in several pathogenic diseases, and we have previously provided strong evidences that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive Group A Streptococcus (GAS) infections, including sepsis and necrotizing soft tissue infections (NSTIs). Our initial studies with conventional mouse strains revealed...

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Source

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Identifiers

PMID: 27399650
DOI: 10.1371/journal.ppat.1005732
PMCID: PMC4939974

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Source receipt: pubmed, retrieved 7 Sept 2026.

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