Article
The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb.
Development (Cambridge, England) - 1 Feb 2003
Ros Maria A, Dahn Randall D, Fernandez-Teran Marian, Rashka Kay, Caruccio Nicholas C, Hasso Sean M, Bitgood J James, Lancman Joseph J, Fallon John F
Abstract excerpt
We have analyzed a new limb mutant in the chicken that we name oligozeugodactyly (ozd). The limbs of this mutant have a longitudinal postaxial defect, lacking the posterior element in the zeugopod (ulna/fibula) and all digits except digit 1 in the leg. Classical recombination experiments show that the limb mesoderm is the defective tissue layer in ozd limb buds. Molecular analysis revealed that the ozd limbs...
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