Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation of the chicken Lmbr1 coding sequence and characterization of its role during chick limb development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2004

Maas Sarah A, Fallon John F

Abstract excerpt

In the developing amniote limb, anteroposterior (A/P) patterning is controlled through secretion of the Sonic Hedgehog (SHH) protein by cells in the zone of polarizing activity (ZPA) located in the posterior mesoderm. In the chicken mutant oligozeugodactyly (ozd), Shh is expressed normally in the entire embryo with the exception that it is undetectable in the developing limbs; this results in the loss of specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chick Embryo

Share to Electroporation

Share to Expressed Sequence Tags

Share to Extremities

Share to Hedgehog Proteins

Share to In Situ Hybridization

Source

Identifiers

PMID: 14991708
DOI: 10.1002/dvdy.10502

Genes

LMBR1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of the chicken Lmbr1 coding sequence and characterization of its role during chick limb development.PMID 14991708Read ↗

Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.Semantic proximity Read ↗

Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).Semantic proximity Read ↗

The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development.Semantic proximity Read ↗

Identification of spontaneous mutations within the long-range limb-specific Sonic hedgehog enhancer (ZRS) that alter Sonic hedgehog expression in the chicken limb mutants oligozeugodactyly and silkie breed.Semantic proximity Read ↗

Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development.Semantic proximity Read ↗

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.Semantic proximity Read ↗

The chick limb: embryology, genetics and teratology.Semantic proximity Read ↗

The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb.Semantic proximity Read ↗

A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.Semantic proximity Read ↗

Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.Semantic proximity Read ↗

A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice.Semantic proximity Read ↗

Conserved requirement of Lim1 function for cell movements during gastrulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.