Article
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs.
Cell - 5 Nov 1993
Dollé P, Dierich A, LeMeur M, Schimmang T, Schuhbaur B, Chambon P, Duboule D
Abstract excerpt
Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations along all body axes suggesting the existence of a general multiaxial patterning system. In limbs,...
Topics
- Animals
- Bone and Bones
- Calcification, Physiologic
- DNA-Binding Proteins
- Extremities
- Genes, Homeobox
- Homeodomain Proteins
- Limb Deformities, Congenital
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains