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Article

The stalling of transcription at abasic sites is highly mutagenic.

Molecular and cellular biology - 1 Jan 2003

Yu Sung-Lim, Lee Sung-Keun, Johnson Robert E, Prakash Louise, Prakash Satya

Abstract excerpt

Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites and that also lack the RAD26 gene, a homolog of the human Cockayne syndrome group B (CSB) gene, and, importantly, a...

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Identifiers

PMID: 12482989
DOI: 10.1128/MCB.23.1.382-388.2003
PMCID: PMC140683

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The stalling of transcription at abasic sites is highly mutagenic.PMID 12482989Read ↗

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