Article
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.
Genes & development - 15 Apr 2001
Haracska L, Unk I, Johnson R E, Johansson E, Burgers P M, Prakash S, Prakash L
Abstract excerpt
Abasic (AP) sites are one of the most frequently formed lesions in DNA, and they present a strong block to continued synthesis by the replicative DNA machinery. Here we show efficient bypass of an AP site by the combined action of yeast DNA polymerases delta and zeta. In this reaction, Poldelta inserts an A nucleotide opposite the AP site, and Polzeta subsequently extends from the inserted nucleotide. Consistent...
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