Article
Spt4 modulates Rad26 requirement in transcription-coupled nucleotide excision repair.
The EMBO journal - 1 Dec 2000
Jansen L E, den Dulk H, Brouns R M, de Ruijter M, Brandsma J A, Brouwer J
Abstract excerpt
The nucleotide excision repair machinery can be targeted preferentially to lesions in transcribed sequences. This mode of DNA repair is referred to as transcription-coupled repair (TCR). In yeast, the Rad26 protein, which is the counterpart of the human Cockayne syndrome B protein, is implicated specifically in TCR. In a yeast strain genetically deprived of global genome repair, a deletion of RAD26 renders cells...
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