Article
Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.
Nature communications - 1 Dec 2021
Yan Chunli, Dodd Thomas, Yu Jina, Leung Bernice, Xu Jun, Oh Juntaek, Wang Dong, Ivanov Ivaylo
Abstract excerpt
Transcription-coupled repair is essential for the removal of DNA lesions from the transcribed genome. The pathway is initiated by CSB protein binding to stalled RNA polymerase II. Mutations impairing CSB function cause severe genetic disease. Yet, the ATP-dependent mechanism by which CSB powers RNA polymerase to bypass certain lesions while triggering excision of others is incompletely understood. Here we build...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.