Article
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Molecular and cellular biology - 1 Jan 2003
Hsieh James J-D, Ernst Patricia, Erdjument-Bromage Hediye, Tempst Paul, Korsmeyer Stanley J
Abstract excerpt
The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3,969-amino-acid nuclear protein homologous to Drosophila trithorax and is required to maintain proper Hox gene expression. Chromosome translocations in human leukemia disrupt MLL (11q23), generating chimeric proteins between the N terminus of MLL and multiple translocation partners. Here we report that MLL is normally cleaved at two conserved sites...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.