Article
New insight into the molecular mechanisms of MLL-associated leukemia.
Leukemia - 1 Feb 2005
Li Z-Y, Liu D-P, Liang C-C
Abstract excerpt
Rearrangements of the MLL gene (ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in adult and pediatric cases of primary acute leukemias and also found in cases of therapy-related secondary leukemias. Studies on mouse models of MLL translocation and cell lines containing MLL rearrangements showed that the MLL gene linked chromosomal rearrangements to cellular differentiation and tumor...
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