Back to search

Article

Effects of Mixed Lineage Leukaemia, the human homologue of Trithorax, and its leukaemic fusion proteins in Drosophila melanogaster

2002-01-01

Abstract excerpt

Mixed Lineage Leukaemia (MLL) refers to the protein implicated in translocating with over 30 partner genes to form fusion proteins that lead to the development of acute leukaemia. MLL mediated leukaemia predominantly afflicts children under 5 years of age or younger, and is associated with very poor survival rates. Although MLL shares limited homology with the <i>Drosophila</i> Trithorax (TRX) protein, both MLL an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c85a9bdc-7696-5f76-8088-134e7c1b8b9c
DOI
10.21954/ou.ro.0000fbda
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Effects of Mixed Lineage Leukaemia, the human homologue of Trithorax, and its leukaemic fusion proteins in Drosophila melanogasterDOI 10.21954/ou.ro.0000fbda
Mechanisms of leukemogenesis by MLL fusion proteinsSemantic proximity
Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.Semantic proximity
The molecular biology of mixed lineage leukemiaSemantic proximity
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in <i>Drosophila</i> larvaeSemantic proximity
MLL: how complex does it get?Semantic proximity
Mixed lineage leukemia: roles in human malignancies and potential therapySemantic proximity
THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIASSemantic proximity
ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemiaSemantic proximity
Chromatin modifying activity of leukaemia associated fusion proteinsSemantic proximity
MLL leukemia and future treatment strategies.Semantic proximity
Molecular and Epigenetic Mechanisms of MLL in Human LeukemogenesisSemantic proximity
The human leukemic fusion protein MLL-AF4 promotes autophagy and cell death in the fat body of <i>Drosophila melanogaster</i>Semantic proximity
Select a neighboring publication to make it the new centre.