Article
Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.
Genesis (New York, N.Y. : 2000) - 1 Aug 2001
Ayton P, Sneddon S F, Palmer D B, Rosewell I R, Owen M J, Young B, Presley R, Subramanian V
Abstract excerpt
The mixed lineage leukemia gene (MLL) was originally identified through its involvement in reciprocal translocations in leukemias. MLL codes for a large multidomain protein and bears homology to the Drosophila developmental control gene trithorax in two small domains in the amino terminal region, the central zinc finger domain and the carboxy SET domain. Like the Drosophila trx, MLL has also been shown to be a...
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