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Article

ECSASB2 mediates MLL degradation during hematopoietic differentiation

16 Dec 2011

Abstract excerpt

Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most common genetic alterations in human leukemia. Here we show that ASB2, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL degradation through interaction with the PHD/Bromodomain region of MLL. Forced expression of ASB2 degrades MLL and...

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Acute Myeloid Leukemia Research
Protein Degradation and Inhibitors
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22174154
DOI: 10.1182/blood-2011-06-362079

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