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Article

Mechanisms of Transformation by MLL

1 Jan 2004

Abstract excerpt

Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. Transformation by rearranged forms of MLL1, including in-frame fusion proteins, partial tandem duplications, and amplification of MLL1 through upregulation of Hox gene and cofactor expression apparently results in...

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Identifiers

PMID: 15663355
DOI: 10.1615/critreveukaryotgeneexpr.v14.i4.10

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