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Article

MLL becomes functional through intra-molecular interaction not by proteolytic processing.

PloS one - 1 Jan 2013

Yokoyama Akihiko, Ficara Francesca, Murphy Mark J, Meisel Christian, Hatanaka Chikako, Kitabayashi Issay, Cleary Michael L

Abstract excerpt

The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by formation of an intra-molecular complex and proteolytic cleavage. However the biological significance of these two post-transcriptional events remains unclear. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24040009
DOI: 10.1371/journal.pone.0073649
PMCID: PMC3769346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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