Article
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
The Journal of clinical investigation - 1 Oct 2006
Dorrance Adrienne M, Liu Shujun, Yuan Weifeng, Becknell Brian, Arnoczky Kristy J, Guimond Martin, Strout Matthew P, Feng Lan, Nakamura Tatsuya, Yu Li, Rush Laura J, Weinstein Michael, Leone Gustavo, Wu Lizhao, Ferketich Amy, Whitman Susan P, Marcucci Guido, Caligiuri Michael A
Abstract excerpt
We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial tandem duplication (PTD) of exons 5 through 11 in the absence of a partner gene, occurring in approximately 4%-7% of patients with acute myeloid leukemia (AML) and normal cytogenetics, and associated with a poor prognosis. The mechanism by which the MLL PTD...
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