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Article

MLL fusions: Pathways to leukemia

1 Jul 2009

Abstract excerpt

Human leukemias with chromosomal band 11q23 aberrations that disrupt the MLL/HRX/ALL-1 gene portend poor prognosis. MLL associated leukemias account for the majority of infant leukemia, approximately 10% of adult de novo leukemia and approximately 33% of therapy related acute leukemia with a balanced chromosome translocation. The 500 kD MLL precursor is processed by Taspase1 to generate mature MLL(N320/C180),...

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PMID: 19729989
DOI: 10.4161/cbt.8.13.8924

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