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Article

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.

Molecular and cellular biology - 1 Dec 2004

Ayton Paul M, Chen Everett H, Cleary Michael L

Abstract excerpt

The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric oncoproteins. These invariably contain the amino-terminal 1,400 residues of MLL fused with one of a variety of over 30 distinct nuclear or cytoplasmic partner proteins. Despite the consistent inclusion of the MLL amino-terminal region in leukemia oncoproteins, little is known regarding its...

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Share to Bone Marrow Cells
Share to CpG Islands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Histone-Lysine N-Methyltransferase

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Share to Myeloid-Lymphoid Leukemia Protein

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 15542854
DOI: 10.1128/MCB.24.23.10470-10478.2004
PMCID: PMC529055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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