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Article

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.

Molecular and cellular biology - 1 Jan 2003

Yang Hsin-Sheng, Jansen Aaron P, Komar Anton A, Zheng Xiaojing, Merrick William C, Costes Sylvain, Lockett Stephen J, Sonenberg Nahum, Colburn Nancy H

Abstract excerpt

Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation. A yeast two-hybrid analysis revealed that Pdcd4 associates with the eukaryotic translation initiation factors eIF4AI and eIF4AII. Immunofluorescent confocal microscopy showed that Pdcd4 colocalizes with eIF4A in the cytoplasm....

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Identifiers

PMID: 12482958
DOI: 10.1128/MCB.23.1.26-37.2003
PMCID: PMC140682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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