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PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

7 Dec 2017

Abstract excerpt

The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not known. We here show that mRNA translation stress in cis triggered by the gly-ala repeat sequence of Epstein-Barr virus (EBV)-encoded EBNA1, results in PI3Kδ-dependent...

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PMID: 29235459
DOI: 10.1038/s41467-017-02282-w

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