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Article

Lost in translation: dysregulation of cap-dependent translation and cancer.

Cancer cell - 1 Jun 2004

Bjornsti Mary-Ann, Houghton Peter J

Abstract excerpt

Activation of the phosphatidylinositol 3' kinase-Akt pathway has long been associated with malignant transformation and antiapoptotic signaling. Mutations downstream of Akt that activate the TOR kinase are found in tumor-prone syndromes, while overexpression of translation initiation complex components, such as eIF4E, occurs frequently in human cancer. However, direct roles for TOR signaling or eIF4E...

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Identifiers

PMID: 15193254
DOI: 10.1016/j.ccr.2004.05.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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