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Article

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.

Nucleic acids research - 1 Jan 2014

Fehler Olesja, Singh Priyanka, Haas Astrid, Ulrich Diana, Müller Jan P, Ohnheiser Johanna, Klempnauer Karl-Heinz

Abstract excerpt

The tumor suppressor protein programmed cell death 4 (Pdcd4) has been implicated in the translational regulation of specific mRNAs, however, the identities of the natural Pdcd4 target mRNAs and the mechanisms by which Pdcd4 affects their translation are not well understood. Pdcd4 binds to the eukaryotic translation initiation factor eIF4A and inhibits its helicase activity, which has suggested that Pdcd4...

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Identifiers

PMID: 25190455
DOI: 10.1093/nar/gku800
PMCID: PMC4176178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.PMID 25190455Read ↗

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