Article

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in 40S small ribosomal subunit

2024-05-02

Abstract excerpt

Translation is regulated mainly in the initiation step, and its dysregulation is implicated in many human diseases. Several proteins have been found to regulate translational initiation, including Pdcd4 (programmed cell death gene 4). Pdcd4 is a tumor suppressor protein that prevents cell growth, invasion, and metastasis. It is downregulated in most tumor cells, while global translation in the cell is upregulated....

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Literature Corpus work: 0d005d1f-77a1-5ced-a34f-3c58056fac39
DOI: 10.1101/2024.05.01.592117

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