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Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

2 Feb 2021

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. Children suffering from high-risk and/or metastatic NB often show no response to therapy, and new therapeutic approaches are urgently needed. Malignant tumor development has been shown to be driven by the dysregulation of eukaryotic initiation factors (eIFs) at the translation initiation. Especially the activity of the heterotrimeric eIF4F...

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PMID: 33540613
DOI: 10.3390/cells10020301

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