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Article

Translation initiation: a critical signalling node in cancer.

Expert opinion on therapeutic targets - 1 Nov 2009

Robert Francis, Pelletier Jerry

Abstract excerpt

Mammalian target of rapamycin (mTOR) is a master regulator of translation initiation that controls the recruitment of ribosomes to mRNA templates in response to intracellular and extracellular cues. Evidence suggests that mTOR and its direct downstream targets, S6K and eIF4E/4E-BP, play significant roles in oncogenesis, and that inhibiting this pathway holds promise as an anti-proliferative approach. Recent...

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Identifiers

PMID: 19705976
DOI: 10.1517/14728220903241625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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