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Article

A survival–stratification model of human colorectal carcinomas with β‐catenin and p27<sup>kip1</sup>

3 Dec 2002

Abstract excerpt

BACKGROUND: The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle progression through G1 to S-phase. Lack of p27 is a significant predictor of poor survival in a...

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PMID: 12467060
DOI: 10.1002/cncr.10986

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