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Article

CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.

International journal of cancer - 15 Jun 2010

Firestein Ron, Shima Kaori, Nosho Katsuhiko, Irahara Natsumi, Baba Yoshifumi, Bojarski Emeric, Giovannucci Edward L, Hahn William C, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Alterations in the Wnt/beta-catenin pathway define a key event in the pathogenesis of colon cancer. We have recently shown that CDK8, the gene encoding a cyclin-dependent kinase (CDK) component of the Mediator complex, acts as a colon cancer oncogene that is necessary for beta-catenin activity. H...

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Source

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Identifiers

PMID: 19790197
DOI: 10.1002/ijc.24908
PMCID: PMC3035929

Genes

CDK8
FASN
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19790197-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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