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Article

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21 <sup>WAF1/CIP1</sup> expression and correlates with patient survival

27 Jun 2001

Abstract excerpt

We investigated the expression of the cell cycle regulatory proteins cyclin D1 and p21(WAF1/CIP1) (p21) in human colorectal carcinomas using immunohistochemistry. Cyclin D1 was not detected in normal colonic epithelium; however, expression was observed in 74/126 (58.7%) of the tumour samples studied. Protein was detected in the nucleus in 22/126 (17.4%) and exclusively in the cytoplasm in 52/126 (41.3%) tumours....

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PMID: 11494229
DOI: 10.1002/1097-0215(20010920)95:5<302::aid-ijc1052>3.0.co;2-#

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