β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.

doi:10.1038/s41388-018-0170-y

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Article

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.

Oncogene - 1 Jun 2018

Saponaro Concetta, Sergio Sara, Coluccia Antonio, De Luca Maria, La Regina Giuseppe, Mologni Luca, Famiglini Valeria, Naccarato Valentina, Bonetti Daniela, Gautier Candice, Gianni Stefano, Vergara Daniele, Salzet Michel, Fournier Isabelle, Bucci Cecilia, Silvestri Romano, Passerini Carlo Gambacorti, Maffia Michele, Coluccia Addolorata Maria Luce

Abstract excerpt

Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-catenin signaling negatively regulates the expression of NHERF1 (Na+/H+ exchanger 3 regulating...

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Identifiers

PMID: 29551770
DOI: 10.1038/s41388-018-0170-y
PMCID: PMC6002344

Genes

NHERF1
KRAS
APC
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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