Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.

Cell adhesion and communication - 1 Jan 1998

Berx G, Nollet F, van Roy F

Abstract excerpt

The different proteins of the E-cadherin/catenin cell-cell adhesion complex are believed to play a predominant role in carcinogenesis. Aberrant expression of these proteins has been found in many different human carcinomas, indicating abnormal regulation. In general, inactivating mutations of the human E-cadherin gene are rare; they are, however, highly frequent in infiltrating lobular breast carcinomas and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cadherins
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to APC gene

Share to Gene Expression Regulation, Neoplastic

Share to Mutation

Share to Stomach Neoplasms

Share to Trans-Activators

Source

Identifiers

PMID: 9823469
DOI: 10.3109/15419069809004474

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.PMID 9823469Read ↗

Cadherin and catenin alterations in human cancer.Semantic proximity Read ↗

The role of the E-cadherin/catenin complex in gastrointestinal cancer.Semantic proximity Read ↗

E-cadherin-catenin cell-cell adhesion complex and human cancer.Semantic proximity Read ↗

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression.Semantic proximity Read ↗

The role of E-cadherin-catenin complex: more than an intercellular glue?Semantic proximity Read ↗

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.Semantic proximity Read ↗

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.Semantic proximity Read ↗

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.Semantic proximity Read ↗

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.Semantic proximity Read ↗

The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.Semantic proximity Read ↗

Erbb Receptors and Epithelial-Cadherin–Catenin Complex In Human CarcinomasSemantic proximity Read ↗

Deranged expression of the E‐cadherin/β‐catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.