Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.

doi:10.3109/15419069809004474

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Article

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.

Cell adhesion and communication - 1 Jan 1998

Berx G, Nollet F, van Roy F

Abstract excerpt

The different proteins of the E-cadherin/catenin cell-cell adhesion complex are believed to play a predominant role in carcinogenesis. Aberrant expression of these proteins has been found in many different human carcinomas, indicating abnormal regulation. In general, inactivating mutations of the...

Topics

Breast Neoplasms
Cadherins
Cytoskeletal Proteins
Female
Gene Expression Regulation, Neoplastic
Humans
Mutation
Stomach Neoplasms
Trans-Activators
beta Catenin

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