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Article

c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation.

The American journal of pathology - 1 Aug 2018

Kumaradevan Sowmiya, Lee Shin Yin, Richards Sean, Lyle Chimera, Zhao Qing, Tapan Umit, Jiangliu Yilan, Ghumman Shmyle, Walker Joshua, Belghasem Mostafa, Arinze Nkiruka, Kuhnen Angela, Weinberg Janice, Francis Jean, Hartshorn Kevan, Kolachalama Vijaya B, Cifuentes Daniel, Rahimi Nader, Chitalia Vipul C

Abstract excerpt

The proto-oncogene β-catenin drives colorectal cancer (CRC) tumorigenesis. Casitas B-lineage lymphoma (c-Cbl) inhibits CRC tumor growth through targeting nuclear β-catenin by a poorly understood mechanism. In addition, the role of c-Cbl in human CRC remains largely underexplored. Using a novel quantitative histopathologic technique, we demonstrate that patients with high c-Cbl-expressing tumors had significantly...

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Identifiers

PMID: 30029779
DOI: 10.1016/j.ajpath.2018.05.007
PMCID: PMC6099425

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